Mechanisms of interstrand DNA crosslink repair and human disorders
نویسندگان
چکیده
منابع مشابه
DNA interstrand crosslink repair in mammalian cells.
DNA damage by agents crosslinking the strands presents a formidable challenge to the cell to repair for survival and to repair accurately for maintenance of genetic information. It appears that repair of DNA crosslinks occurs in a path involving double strand breaks (DSBs) in the DNA. Mammalian cells have multiple systems involved in the repair response to such damage, including the Fanconi ane...
متن کاملREV1 and DNA polymerase zeta in DNA interstrand crosslink repair.
DNA interstrand crosslinks (ICLs) are covalent linkages between two strands of DNA, and their presence interferes with essential metabolic processes such as transcription and replication. These lesions are extremely toxic, and their repair is essential for genome stability and cell survival. In this review, we will discuss how the removal of ICLs requires interplay between multiple genome maint...
متن کاملMechanism of Replication-Coupled DNA Interstrand Crosslink Repair
DNA interstrand crosslinks (ICLs) are toxic DNA lesions whose repair occurs in the S phase of metazoans via an unknown mechanism. Here, we describe a cell-free system based on Xenopus egg extracts that supports ICL repair. During DNA replication of a plasmid containing a site-specific ICL, two replication forks converge on the crosslink. Subsequent lesion bypass involves advance of a nascent le...
متن کاملDNA interstrand crosslink repair during G1 involves nucleotide excision repair and DNA polymerase zeta.
The repair mechanisms acting on DNA interstrand crosslinks (ICLs) in eukaryotes are poorly understood. Here, we provide evidence for a pathway of ICL processing that uses components from both nucleotide excision repair (NER) and translesion synthesis (TLS) and predominates during the G1 phase of the yeast cell cycle. Our results suggest that repair is initiated by the NER apparatus and is follo...
متن کاملFANCD2 Hurdles the DNA Interstrand Crosslink
Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.
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ژورنال
عنوان ژورنال: Genes and Environment
سال: 2016
ISSN: 1880-7062
DOI: 10.1186/s41021-016-0037-9